{"id":34,"date":"2026-06-16T16:36:11","date_gmt":"2026-06-16T22:36:11","guid":{"rendered":"https:\/\/schauerlab.colostate.edu\/index.php\/publications\/"},"modified":"2026-09-22T11:41:20","modified_gmt":"2026-09-22T17:41:20","slug":"publications","status":"publish","type":"page","link":"https:\/\/schauerlab.colostate.edu\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Publications<\/h2>\n\n\n
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Preprints and\/or in preparation<\/h4>\n\n\n\n
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  • Timmerman AJ, Brady RE, Lawson VM, Stewart JA, Argueso JL, Schauer GD<\/strong>. Mechanical tuning of replication stress tolerance and genomic stability through the checkpoint mediator Mrc1. bioRxiv: The Preprint Server for Biology; 2026. doi:10.64898\/2026.05.14.725212 PMCID: PMC13192788<\/li>\n\n\n\n
  • Reitman HJ, Uhrig ME, Karns CR, Shaw AE, Mihelich MN, Wiese C, Schauer GD<\/strong>. Hydroxyurea-induced cell cycle arrest in human cells is not caused by dNTP depletion. Manuscript in preparation.<\/li>\n\n\n\n
  • Dixon LD, Radebaugh CA, Schauer GD<\/strong>, Stargel LA. Spn1 and its network of interactions in the RNA Polymerase II complex. Manuscript in Preparation<\/li>\n<\/ul>\n\n\n\n
    <\/div>\n\n\n\n

    Schauer Lab publications<\/h4>\n\n\n\n
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    • Mukherjee, P, Sarker, A, Schauer, GD<\/strong> \u00a0DNA Polymerase \u03b1 has cyclopyrimidine dimer translesion activity that is suppressed during normal replication. In press at Journal of Molecular Biology<\/em>, September 2026.<\/li>\n\n\n\n
    • Mukerhjee, P and Schauer, GD<\/strong>. A simplified translesion polymerase assay. Invited book chapter, Methods in Molecular Biology<\/em> (Springer)<\/em>, 2026.<\/li>\n\n\n\n
    • Shaw AE, Mihelich MN, Whitted JE, Reitman HJ, Timmerman AJ, Tehseen M, Hamdan SM, Schauer GD<\/strong>. Revised mechanism of hydroxyurea-induced cell cycle arrest and an improved alternative. Proc Natl Acad Sci USA<\/em>. 2024 Oct 15;121(42):e2404470121.<\/li>\n\n\n\n
    • Shaw AE, Kairamkonda S, Ghodke H, Schauer GD<\/strong>. Biochemical and single-molecule techniques to study accessory helicase resolution of R-loop proteins at stalled replication forks. Methods Enzymol. April 2022; 673:191-225.  <\/li>\n\n\n\n
    • Stewart, JA, Schauer GD<\/strong>, Bhagwat AS. Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks. Nucleic Acids Research<\/em>, 2020 Oct. 19;48(20):e118.<\/li>\n\n\n\n
    • Schauer GD<\/strong>\u2020*, Spenkelink LM\u2020, Lewis JS, Yurieva O, Mueller SH, van Oijen AM*, O\u2019Donnell ME*, Replisome bypass of a protein-based R-loop block by Pif1. Proc Natl Acad Sci USA<\/em>, 2020 Dec. 1; 117(48):30354\u201330361. \u2020co-first author; *corresponding author.<\/li>\n<\/ul>\n\n\n\n
      <\/div>\n\n\n\n

      Previous work<\/h4>\n\n\n\n
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      • Yuan Z, Georgescu R, Schauer<\/strong> GD<\/strong>, O\u2019Donnell ME, Li H. Structure of the polymerase \u03b5 holoenzyme and atomic model of the leading strand replisome. Nat<\/em> Commun<\/em>.; 2020 Jun 22;11(1):3156.<\/li>\n\n\n\n
      • Lewis JS\u2020, Spenkelink LM\u2020, Schauer GD<\/strong>, Yurieva O, Natarajan V, Kaur G, Maher C, Kay C, O\u2019Donnell ME, van Oijen AM. Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication. Molecular Cell,<\/em> 2020 Jan 2; 77, 17-25; \u2020co-first author<\/li>\n\n\n\n
      • Schauer GD<\/strong>\u2020, Wasserman MR\u2020, O\u2019Donnell ME*, Liu S*.\u00a0 Replisome preservation by a single-stranded DNA gate in the CMG helicase. Cell<\/em>, 2019 Jul 25;178(3):600-611.e16. \u2020co-first author; *co-corresponding author<\/li>\n\n\n\n
      • Whinn K,Kaur G,<\/strong> Lewis, JS, Schauer GD,<\/strong> M\u00fcller S, Jergic S, Naganbabu M, Bruchez M, O\u2019Donnell ME, Dixon N, van Oijen AM, Ghodke H. Nuclease dead Cas9 is a programmable roadblock for DNA replication.  Sci Rep<\/em>. 2019 Sep 16;9(1):13292.<\/li>\n\n\n\n
      • Lewis JS\u2020, Spenkelink LM\u2020, Schauer GD<\/strong>, Hill FR, Georgescu RE, O\u2019Donnell ME, van Oijen AM. Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome. Proc Natl Acad Sci USA<\/em>. 2017 Oct 3;114(40):10630\u201310635. PMCID: PMC5635917; \u2020authors contributed equally.<\/li>\n\n\n\n
      • Schauer GD<\/strong>, Finkelstein J, O\u2019Donnell M. In vitro Assays for Eukaryotic Leading\/Lagging Strand DNA Replication. Bio-Protocol<\/em>. 2017 Sep 20;7(18). PMCID: PMC5659624<\/li>\n\n\n\n
      • Langston LD, Mayle R, Schauer GD<\/strong>, Yurieva O, Zhang D, Yao NY, Georgescu RE, O\u2019Donnell ME. Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. eLife<\/em>. 2017 Sep 4;6. PMCID: PMC5599239<\/li>\n\n\n\n
      • Schauer GD<\/strong>, O\u2019Donnell ME. Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork. Proc Natl Acad Sci USA<\/em>. 2017 Jan 9. PMCID: PMC5278475<\/li>\n\n\n\n
      • Georgescu RE, Schauer GD<\/strong>, Yao NY, Langston LD, Yurieva O, Zhang D, Finkelstein J, O\u2019Donnell ME. Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading\/lagging strand operation. eLife<\/em>. 2015 Apr 30. PMCID: PMC4413876.<\/li>\n\n\n\n
      • Schauer GD<\/strong>, and Sluis-Cremer N. HIV-1 Resistance to Reverse Transcriptase Inhibitors. Handbook of Antimicrobial Resistance<\/em>, M. Gotte, A. Berghuis, G. Matlashewski, M. Wainberg, and D. Sheppard, eds. (Springer).  2014; 1\u201317. DOI: 10.1007\/978-1-4939-0667-3_26-1<\/li>\n\n\n\n
      • Schauer GD<\/strong>, Leuba S, Sluis-Cremer N. Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Biomolecules<\/em>. 2013;3(4):889-904.<\/li>\n\n\n\n
      • Schauer GD<\/strong>, Huber KD, Leuba SH, Sluis-Cremer N. Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence. Nucleic Acids Research<\/em>. 2014 Oct;42(18):11687\u201311696. PMCID: PMC4191400.<\/li>\n\n\n\n
      • Leuba SH, Carney SM, Dahlburg EM, Eells RJ, Ghodke H, Yanamala N, Schauer GD<\/strong>, Klein-Seetharaman J. Early integration of the individual student in academic activities: a novel classroom concept for graduate education in molecular biophysics and structural biology. BMC Biophysics<\/em>. 2014;7:6. PMCID: PMC4134111.<\/li>\n\n\n\n
      • Fagerburg MV, Schauer GD<\/strong>, Thickman KR, Bianco PR, Khan SA, Leuba SH, Anand SP. PcrA-mediated disruption of RecA nucleoprotein filaments–essential role of the ATPase activity of RecA. Nucleic Acids Research<\/em>. 2012;40(17):8416-24. PMCID: PMC3458574.<\/li>\n\n\n\n
      • Graham BW, Schauer GD<\/strong>, Leuba SH, Trakselis MA. Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding. Nucleic Acids Research<\/em>. 2011;39(15):6585-95. PMCID: PMC3159478.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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